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The principal cytochrome P450 isoenzyme included appears to be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to eighty five% of an oral dose appears from the urine within just 24 hrs of administration, most as being the glucuronide conjugate, with smaller amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity details